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Animal Models for Ophthalmological Rare Diseases
Ophthalmological rare diseases are mostly inherited blinding eye diseases that severely damage the structure and function of the eye and seriously affect the physical and mental health of patients and their offspring. Ophthalmic diseases designated as orphan conditions have heterogeneous causes, including inherited genetic defects (e.g., Leber's congenital claustrophobia (LCA) and Stargardt's disease), autoimmune syndromes, or neovascular damage.
In recent years, the underlying genetic factors of a range of ophthalmological rare diseases have been identified, and the development of relevant animal models has led to significant breakthroughs in preclinical research. The establishment and availability of stable and reliable animal models for ophthalmological rare diseases have incalculable potential for disease pathogenesis studies, drug target studies, and evaluation of therapeutic effects. Current orphan drug designations in this therapeutic area cover a wide range of therapeutic strategies, including gene therapy, peptides that induce immune tolerance, and neovascularization.
Animal Models of Retinitis Pigmentosa
Animal Models of Stargardt's Disease
Animal Models of Leber's Congenital Amaurosis
In recent years, the underlying genetic factors of a range of ophthalmological rare diseases have been identified, and the development of relevant animal models has led to significant breakthroughs in preclinical research. The establishment and availability of stable and reliable animal models for ophthalmological rare diseases have incalculable potential for disease pathogenesis studies, drug target studies, and evaluation of therapeutic effects. Current orphan drug designations in this therapeutic area cover a wide range of therapeutic strategies, including gene therapy, peptides that induce immune tolerance, and neovascularization.
Animal Models of Retinitis Pigmentosa
Animal Models of Stargardt's Disease
Animal Models of Leber's Congenital Amaurosis
cathyysmith 185 days ago
Until 13/12/2023 00:00:00
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