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Tissue Cross-Reactivity Evaluation

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Introduction of Tissue Cross-Reactivity Evaluation
Tissue cross-reactivity (TCR) is essential to the development of monoclonal antibodies and other related biologics, primarily to identify off-target binding, but may also be used to identify previously unknown target binding sites. Monoclonal antibodies usually have specific immune properties. There are antigenic determinants that are the same or similar to specific target sites in normal human tissues and are prone to adverse reactions. Therefore, TCR evaluation is an important method to detect the safety of monoclonal antibody drugs. It provides an important reference for drug clinical toxicity prediction and monitoring.

cathyysmith 143 days ago

Health | biology

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